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2024-07-19
Immunophenotype of Adult T-cell Leukemia/Lymphoma and Its Clinicopathological Significance
Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell tumor caused by human T-lymphotropic virus type 1 (HTLV-1), composed of lymphocytes with severe nuclear pleomorphism.
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2024-07-15
TOX can serve as a new diagnostic marker for T-LGLL.
T-cell large granular lymphocyte leukemia (T-LGLL) is a chronic, mature lymphoproliferative disorder characterized by absolute (> 2 × 10^9/l) or relative (50%) lymphocytosis. Although its course is usually slow, symptoms may worsen when cytotoxic responses against hematopoietic cells lead to cytopenia.
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2024-07-05
The Role of the Microenvironment in the Pathogenesis of Glioma
Gliomas are a diverse group of primary tumors of the central nervous system (CNS). Well-defined low-grade tumors such as pilocytic astrocytomas are the most common primary brain tumor types in children and adolescents. In contrast, diffuse gliomas, such as isocitrate dehydrogenase wild-type (IDH-wt) glioblastoma (GBM), are the most common primary malignant brain tumors in adults.
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2024-06-22
GP2 (Glycoprotein 2) is widely distributed among species, present in mammals, poultry, and even some fish; this wide distribution indicates the importance of GP2's conservation across different animal species.
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2024-06-14
High-grade serous carcinoma (HGSC) is a malignant tumor and the most common and aggressive histological type of ovarian cancer. It typically presents with rapidly dividing and highly atypical cells, characterized by significant nuclear atypia and prominent nucleoli.
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2024-06-14
BRAF Gene Mutation and Selection of Testing Schemes
Rat sarcoma (RAS)/Rapidly Accelerated Fibrosarcoma (RAF)/Mitogen-Activated Protein Kinase Kinase (MEK)/Extracellular Signal-Regulated Kinase (ERK) or Mitogen-Activated Protein Kinase (MAPK) signaling pathway is a key intracellular signaling pathway that mediates growth signal responses essential for cell proliferation and survival.
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