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2024-08-30
CDH17, the rising star of gastrointestinal tumors
CDH17 (Cadherin 17), also known as liver-intestinal cadherin, is a non-classical member of the calcium-dependent protein CDH superfamily.
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2024-08-23
The Differential Application of Claudin18.2 in Gastric-type Adenocarcinoma of the Cervix
The incidence of endocervical adenocarcinoma (ECA) is estimated to account for 20% to 25% of all invasive cervical cancers, showing a concerning upward trend. Human papillomavirus (HPV) is widely recognized as an important factor in the etiology of cervical adenocarcinoma.
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2024-08-16
Expression of PDGFRA Immunohistochemistry in Gastrointestinal Stromal Tumors
Gastrointestinal stromal tumors (GISTs) are malignant tumors originating from Cajal cells or primitive mesenchymal cells differentiating towards them, and are the most common mesenchymal tumors of the gastrointestinal tract.
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2024-07-19
Immunophenotype of Adult T-cell Leukemia/Lymphoma and Its Clinicopathological Significance
Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell tumor caused by human T-lymphotropic virus type 1 (HTLV-1), composed of lymphocytes with severe nuclear pleomorphism.
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2024-07-15
TOX can serve as a new diagnostic marker for T-LGLL.
T-cell large granular lymphocyte leukemia (T-LGLL) is a chronic, mature lymphoproliferative disorder characterized by absolute (> 2 × 10^9/l) or relative (50%) lymphocytosis. Although its course is usually slow, symptoms may worsen when cytotoxic responses against hematopoietic cells lead to cytopenia.
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2024-07-05
The Role of the Microenvironment in the Pathogenesis of Glioma
Gliomas are a diverse group of primary tumors of the central nervous system (CNS). Well-defined low-grade tumors such as pilocytic astrocytomas are the most common primary brain tumor types in children and adolescents. In contrast, diffuse gliomas, such as isocitrate dehydrogenase wild-type (IDH-wt) glioblastoma (GBM), are the most common primary malignant brain tumors in adults.
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