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CD45 Antibody Reagent (Immunohistochemistry)
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CD45 Antibody Reagent (Immunohistochemistry)
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CD45, also known as LCA (Leukocyte Common Antigen), is a protein family composed of five or more high molecular weight glycoproteins. It is expressed in almost all hematopoietic cells: T and B lymphocytes, granulocytes, monocytes, macrophages, immature red blood cells, and megakaryocytes, but not expressed in mature red blood cells, platelets, and non-hematopoietic tissues. It can be used to distinguish lymphoma/leukemia from non-hematopoietic tissue tumors (such as undifferentiated small cell carcinoma, small round cell sarcoma). CD45 positivity is a poor prognostic factor for patients with multiple myeloma. It is mainly used for differential diagnosis between lymphoma and carcinoma, sarcoma, malignant melanoma, and seminoma.
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