微信公众号
Product Center
Related Products
SOX-10 Antibody Reagent
Product Name:
SOX-10 Antibody Reagent
Item Number:
CTB263
Specifications
SOX-10 Antibody Reagent (Immunohistochemistry)
Monoclonal antibody
d1903B20
Nucleus
Skin, malignant melanoma
3/6/12ml
SOX-10 (SRY-related HMG-box 10, sex-determining region Y-box protein 10 gene) is a neural crest transcription factor that plays an important role in the differentiation, maturation, and functional maintenance of Schwann cells and melanocytes. It is located on chromosome 22q13.1 and is a member of the SOX gene family. In normal tissues, it is expressed in glial cells, Schwann cells, melanocytes, and myoepithelial cells (salivary glands, bronchi, and mammary glands). It is positively expressed in almost all nevi and malignant melanomas, neurofibromas, malignant melanomas with fibrous tissue proliferation, neurofibromas, and granular cell tumors; it is also expressed in brain astrocytomas and oligodendrogliomas, PNET, triple-negative breast cancer, salivary gland adenoid cystic carcinoma, acinic cell carcinoma, epithelial-myoepithelial carcinoma, myoepithelial tumors, and others. It serves not only as a marker for Schwann cell and melanocyte tumors but also as a marker for soft tissue myoepithelial tumors. It is mainly used in research related to melanoma and tumors derived from the neural crest.
Contact Us
Category