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Villin (microtubule-associated protein) antibody reagent
Product Name:
Villin (microtubule-associated protein) antibody reagent
Item Number:
CTB118
Specifications
Villin (Microtubule) Antibody Reagent (Immunohistochemistry)
Rabbit monoclonal antibody
12229F1n
Cytoplasm, membrane
Colon cancer
3/6/12ml
Villin is a cytoskeletal protein with a molecular weight of 95 kDa. It is a calcium-dependent actin-binding protein with multiple functions including bundling, severing, capping, and nucleation. It is positively expressed in digestive and urinary system tissues with brush border structures such as intestinal epithelial cells, gallbladder, renal proximal tubules, and testicular efferent ducts, while most other tissues lacking brush borders, such as lung, skin, ovary, and endometrium, are negative. It is highly expressed in gastrointestinal cancer, pancreatic cancer, gallbladder cancer, and cholangiocarcinoma tissues, but rarely positive in ovarian serous carcinoma, urothelial carcinoma, and prostate cancer. It can be used for differential diagnosis between tumors of intestinal epithelial origin and non-intestinal epithelial tumors; it also serves as a reference marker for the diagnosis of gastrointestinal neuroendocrine tumors; combined with CDX2, it aids in inferring the primary site of metastatic tumors.
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