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PAX-5 Protein Antibody Reagent
Product Name:
PAX-5 Protein Antibody Reagent
Item Number:
CTB224
Specifications
Hefei: PAX-5 antibody reagent (immunohistochemistry) Nanjing: PAX-5 antibody reagent (immunohistochemistry)
Rabbit monoclonal antibody
12215H11P
Nucleus
Tonsil
3/6/12ml
Pax-5 (Paired box gene 5) is a member of the Pax nuclear transcription factor family, located on chromosome 9p13, encoding the B cell-specific activator protein (BSAP). During the early development stage of B cells, Pax-5 can influence the expression of B cell-specific genes such as CD19 and CD20. This protein plays an important role in the development of B cells and neurons. It is mainly expressed in the nuclei of pro-B cells and mature B cells, but not expressed in plasma cells; positive expression is observed in classical Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma; positive expression is also seen in Merkel cell carcinoma and small cell carcinoma; plasma cell tumors, multiple myeloma, plasmablastic lymphoma, as well as T cell and T cell-derived tumors are usually negative. It is mainly used for the diagnosis of B cell and B cell-derived tumors.
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