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Synaptophysin protein antibody reagent
Product Name:
Synaptophysin protein antibody reagent
Item Number:
CTB205
Specifications
Synaptophysin Antibody Reagent (Immunohistochemistry)
Rabbit monoclonal antibody
12918A2n
Cytoplasm
Neuroendocrine cells
3/6/12ml
Syn (Synaptophysin) is a 38kDa glycoprotein primarily located in the membranes of presynaptic vesicles of neurons. It is normally expressed in the adrenal medulla, islets of Langerhans, parafollicular C cells of the thyroid, chief cells of the parathyroid, anterior pituitary cells, carotid body, neuroendocrine cells of the skin and visceral epithelium, astrocytes in the central nervous system, and neuroendocrine cells of the gastrointestinal mucosa. It is mainly used for the diagnosis and differential diagnosis of neuroendocrine tumors, such as small cell lung carcinoma and medullary thyroid carcinoma. Positive expression can also be seen in Merkel cell carcinoma, pheochromocytoma, ganglionic neuroblastoma, ganglioneuroma, paraganglioma, and neuroblastoma, as well as in Ewing's sarcoma.
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