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GST-π Protein Antibody Reagent
Product Name:
GST-π Protein Antibody Reagent
Item Number:
CTB184
Specifications
GST-π Antibody Reagent (Immunohistochemistry)
Monoclonal antibody
d718D4T
Nucleus, cytoplasm
Lung cancer, colon adenocarcinoma
3/6/12ml
1. GST-π is a multifunctional drug-metabolizing enzyme, accounting for 90% of the four GST subtypes. It is present in human cytoplasm and mitochondria and is widely distributed in organs throughout the body, mainly in the urinary, digestive, and respiratory epithelium, with the highest content in the liver and kidneys. It primarily catalyzes the conjugation of GSH with a wide range of electrophilic substances to form GS-X, which is then expelled from the cell to achieve detoxification.
GST-π is highly expressed in various tumors and is associated with tumor drug resistance (to agents such as adriamycin, cisplatin, nitrogen mustard, cyclophosphamide, and tumor necrosis factor). Therefore, this antibody is mainly used in research on cellular drug resistance.
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