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S100 Protein Antibody Reagent
Product Name:
S100 Protein Antibody Reagent
Item Number:
CTB072
Specifications
S100 Antibody Reagent (Immunohistochemistry)
Monoclonal antibody
d1912A30
Nucleus, cytoplasm
Appendix, mammary gland
3/6/12ml
S100 is a soluble acidic protein, composed of α and β chains forming a dimer, capable of existing in three structural forms: S100ao (α chain), S100a (α chain-β chain), and S100b (β chain). It is widely present in mesenchymal-derived cells and lymphohematopoietic tissues, such as glial cells, melanocytes, chondrocytes, Schwann cells, adipocytes, myoepithelial cells, follicular dendritic cells, and Langerhans cells. It is mainly expressed in nervous tissue, pituitary gland, carotid body, adrenal medulla, salivary glands, and some mesenchymal tissues. It is primarily used for the diagnosis and differential diagnosis of astrocytoma, glioblastoma, oligodendroglioma, ependymoma, schwannoma, neurofibroma, malignant melanoma, and liposarcoma. S100 has high sensitivity for all types of malignant melanoma and is often used in combination with Melan A and Melanoma for melanoma diagnosis.
It can be used for the differential diagnosis of the following tumors:
(1) Liposarcoma versus other myxoid tumors;
(2) Schwannoma versus leiomyoma;
(3) Sclerosing adenosis of the breast versus tubular adenocarcinoma of the breast;
(4) Spindle cell type malignant melanoma versus spindle cell carcinoma.
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