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ALK Protein Antibody Reagent
Product Name:
ALK Protein Antibody Reagent
Item Number:
CTB060
Specifications
ALK Antibody Reagent (Immunohistochemistry)
Rabbit monoclonal antibody
12113F7K
Cytoplasm, nucleus, membrane
Lung adenocarcinoma, appendix
3/6/12ml
ALK (Anaplastic Lymphoma Kinase, CD246) is a tyrosine kinase transmembrane receptor with a molecular weight of 200 kDa. In normal tissues, only a few cells express ALK. In tumor cases, literature indicates that ALK is expressed in anaplastic large cell lymphoma, inflammatory myofibroblastic tumor, rhabdomyosarcoma, leiomyoma, and lung adenocarcinoma. It is mainly used for the differential diagnosis between anaplastic large cell lymphoma and Hodgkin lymphoma. Patients with ALK-positive anaplastic large cell lymphoma have a better prognosis than those who are ALK-negative; it can also be used to detect bone marrow metastasis in anaplastic large cell lymphoma. Additionally, ALK-positive NSCLC patients are suitable candidates for crizotinib treatment.
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