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GFAP Protein Antibody Reagent
Product Name:
GFAP Protein Antibody Reagent
Item Number:
CTB046
Specifications
Glial Fibrillary Acidic Protein (GFAP) Antibody Reagent (Immunohistochemistry)
Rabbit monoclonal antibody
12712D12P
Cytoplasm
Brain
3/6/12ml
Glial fibrillary acidic protein (GFAP), a cytoskeletal component and a type of intermediate filament. It marks astrocytes, ependymal cells, and their tumors.
Applications:
1. Expressed in astrocytes, ependymal cells, and retinal Muller cells, thus it can be used for diagnosing tumors originating from these cells and for differentiating gliomas from meningiomas. However, it is not expressed in mature oligodendrocytes (oligodendrocyte negative);
2. It can react with Schwann cells, myoepithelial cells, Kupffer cells, and some chondrocytes, so tumors containing these components may show GFAP reactivity (50% of soft tissue myoepitheliomas express GFAP);
3. It can serve as a secondary marker antibody for malignant peripheral nerve sheath tumors (30% of cases show focal GFAP expression).
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